PINKY PEPPER SHADOW DOG
Irish red and white setter
Reg number: ČLP/RWS/261/13; import: PRK.VII-13430
Breeder: Judyta + Beata + Robert Gnyp
We done x-rays and this health test after Cody was more than 1,5year old, after training and after passed working field trials.
All pedigree are HD negative, both parents are HD A, all tested siblings are HD A, so we are more than sure that this bloodline does not suffer from increase incidence of adverse dysplasia.
So why we have C? Most likely wrong x-rays, but it is possible to do it only once...
Canine leukocyte adhesion deficiency (CLAD)
CLAD is autosomal recessive inherited disease. That means the disease affects dogs with P/P (positive / positive) genotype only. The dogs with P/N (positive / negative) genotype are clinically without any symptom. They are genetically considered carriers of the disease (heterozygotes). In offspring of two heterozygous animals following genotype distribution can be expected: 25 % N/N (healthy non-carriers), 25 % P/P (affected), and 50 % N/P (healthy carriers). Because of high risk of producing affected offspring, mating of two N/P animals (carriers) can not be recommended. Molecular genetic test is based on direct DNA sequencing and allows detecting of presence or absence of the mutations and determining the carriers.
Clinically, CLAD is manifested by repeatedly returning infections, bad wounds curing, immunosuppression, skin and marrow infections. Affected puppies are usually smaller and slower developing. From the beginning, they suffer from various infections (umbilical cord, tonsillitis and teeth ridge) and they are more vulnerable. Later, marrow inflammation appears; the affected animal has movement difficulties and finally is not able to stand up. Affected individuals may not show at the same time all symptoms described above.
text from genetic laboratory Genomia, www.genomia.cz